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近亲繁殖对发病率的影响:一、对巴西白人和黑人进行的两项调查的三项分析(一项以堂/表亲及同胞作为对照)

Inbreeding effect on morbidity: I. Three analyses (one with cousin and sib controls) of two surveys among Brazilian whites and Negroes.

作者信息

Ruas P M, Freire-Maia N

出版信息

Am J Med Genet. 1984 Jul;18(3):381-6. doi: 10.1002/ajmg.1320180304.

Abstract

Data from two surveys performed in Brazil and involving 5,719 persons have been subdivided into three subsamples (one with cousin and sib controls). The totals led to estimates of B (abnormal equivalents per gamete) around 0.5, of A (the damage in a noninbred population) around 0.01-0.02, and of B/A from 14 to 77. No statistically significant difference was found between whites and nonwhites (mulattoes and Negroes). Inbreeding seems to disclose a predominantly mutational load.

摘要

来自巴西进行的两项调查、涉及5719人的数据已被细分为三个子样本(一个有堂兄弟姐妹和同胞作为对照)。总体数据得出B(每个配子的异常当量)约为0.5,A(非近亲繁殖群体中的损伤)约为0.01 - 0.02,B/A为14至77。白人与非白人(混血儿和黑人)之间未发现统计学上的显著差异。近亲繁殖似乎揭示了一种主要的突变负荷。

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