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用同源抗原致敏的豚鼠的免疫反应。

Immunological response of guinea pigs sensitized with homologous antigens.

作者信息

Alonso A, de Cerezo J M, Gonzalez N, Bueno M P, Mancini R S

出版信息

Am J Reprod Immunol (1980). 1984 Jul-Aug;6(1):14-8. doi: 10.1111/j.1600-0897.1984.tb00102.x.

DOI:10.1111/j.1600-0897.1984.tb00102.x
PMID:6476181
Abstract

The chemical composition of some "immunologically" pure antigens isolated from guinea pig testis and spermatozoa was correlated with their antigenic behavior. Their immunological responses were compared to select the best materials for a further isolation of chemically pure antigens. The glycoprotein extracted from the spermatozoa (T Gly) has the highest immunological potency and seems to be a T and B, depending antigen, able to induce high humoral and cell responses producing germinal cell damage, testicular lesions, and aspermatogenesis.

摘要

从豚鼠睾丸和精子中分离出的一些“免疫”纯抗原的化学成分与其抗原行为相关。比较它们的免疫反应,以选择最佳材料用于进一步分离化学纯抗原。从精子中提取的糖蛋白(T Gly)具有最高的免疫效力,似乎是一种T细胞和B细胞依赖性抗原,能够诱导强烈的体液和细胞反应,导致生殖细胞损伤、睾丸病变和无精子症。

相似文献

1
Immunological response of guinea pigs sensitized with homologous antigens.用同源抗原致敏的豚鼠的免疫反应。
Am J Reprod Immunol (1980). 1984 Jul-Aug;6(1):14-8. doi: 10.1111/j.1600-0897.1984.tb00102.x.
2
Studies on sperm antigenicity. 2. In vivo and in vitro cellular reactivity in guinea pigs sensitized to homologous and heterologous spermatozoal autoantigens.精子抗原性研究。2. 对同种和异种精子自身抗原致敏的豚鼠体内和体外细胞反应性
Fertil Steril. 1975 Oct;26(10):1024-34.
3
Aspermatogenesis in the guinea pig induced by testicular tissue and adjuvants.睾丸组织和佐剂诱导豚鼠无精子生成
J Exp Med. 1953 May;97(5):711-26. doi: 10.1084/jem.97.5.711.
4
Aspermatogenesis, anaphylaxis, and cutaneous sensitization induced in the guinea pig by homologous testicular extract.同源睾丸提取物在豚鼠中诱导的无精子症、过敏反应和皮肤致敏。
J Exp Med. 1955 Jun 1;101(6):591-604. doi: 10.1084/jem.101.6.591.
5
Immunological unresponsiveness during induction of experimental autoimmune orchitis in guinea-pigs: studies in vivo and in vitro.豚鼠实验性自身免疫性睾丸炎诱导过程中的免疫无反应性:体内和体外研究
Immunology. 1979 Jan;36(1):95-102.
6
Cell-mediated and humoral immune responses to aspermatogenic antigen in experimental allergic orchitis in the guinea-pig.豚鼠实验性变应性睾丸炎中针对无精子生成抗原的细胞介导免疫和体液免疫反应
J Reprod Fertil. 1983 Sep;69(1):279-88. doi: 10.1530/jrf.0.0690279.
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[Cytological localization and pathogenic power of spermatozoa autoantigens in guinea pigs].[豚鼠精子自身抗原的细胞学定位及致病力]
Ann Inst Pasteur (Paris). 1970 Apr;118(4):513-24.
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Suppression of experimental allergic orchitis and cellular immune response in the guinea pig by pretreatment with testis antigen in incomplete Freund's adjuvant.用睾丸抗原加不完全弗氏佐剂预处理对豚鼠实验性变应性睾丸炎及细胞免疫反应的抑制作用
Int Arch Allergy Appl Immunol. 1982;69(1):40-9. doi: 10.1159/000233144.
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[Immunoluminescent detection of antibodies to testicular antigens in experimental autoimmune orchitis].[实验性自身免疫性睾丸炎中睾丸抗原抗体的免疫荧光检测]
Biull Eksp Biol Med. 1979 Dec;88(12):695-8.
10
Immunological effects of thermal injury. I. Inhibition of spermatogenesis in guinea pigs.热损伤的免疫学效应。I. 对豚鼠精子发生的抑制作用。
J Exp Med. 1969 Dec 1;130(6):1411-25. doi: 10.1084/jem.130.6.1411.