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作为新皮质柱状组织发育基础的脑室层镶嵌现象。新生小鼠的3H-胸腺嘧啶核苷放射自显影研究。

Mosaicism of the ventricular layer as the developmental basis of neocortical columnar organization. A 3H-thymidine autoradiographic study in newborn mice.

作者信息

Reznikov K Y, Fülöp Z, Hajós F

出版信息

Anat Embryol (Berl). 1984;170(1):99-105. doi: 10.1007/BF00319464.

DOI:10.1007/BF00319464
PMID:6476412
Abstract

The ratio and local distribution of intensely and weakly labelled neurons as compared with unlabelled neurons were studied in newborn mice by means of autoradiography using 3H-thymidine injected at various embryonic ages. The distribution and migrational properties of intensely labelled neurons suggest that cells contributing to any given cortical layer are not generated simultaneously but in smaller units that correspond to cortical microcolumns. This implies a mosaicity in the genetic potential of the ventricular germinative layer.

摘要

利用在不同胚胎期注射的³H-胸腺嘧啶核苷,通过放射自显影术研究新生小鼠中强标记神经元、弱标记神经元与未标记神经元的比例及局部分布。强标记神经元的分布和迁移特性表明,构成任何给定皮质层的细胞并非同时产生,而是以对应于皮质微柱的较小单元产生。这意味着脑室生发层的遗传潜能具有镶嵌性。

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本文引用的文献

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The time of origin of Cajal-Retzius cells in the rat temporal cortex. An autoradiographic study.大鼠颞叶皮质中Cajal-Retzius细胞的起源时间。一项放射自显影研究。
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