Walsh C, Cepko C L
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115.
Experientia. 1990 Sep 15;46(9):940-7. doi: 10.1007/BF01939387.
Modern techniques which trace lineages of individual progenitor cells have provided some clues about the processes that determine cell fate in the brain, and have also given us some information about migratory patterns of clonally related cells. In many parts of the central nervous system, progenitors are multipotent; single clones can contain multiple neuronal types or even mixtures of neurons and glia. In addition, one can observe a wide distribution in clone size, even when marking is done in a narrow time window. This suggests that progenitor cells may be fairly plastic and responsive to environmental signals. In the developing cortex, clonally related cells are initially grouped near each other, as in the retina and tectum. However, the subsequent migration of these cells from the ventricular zone to the cortex along glial fibers is accompanied by a progressive dispersion of clonally related neurons.
追踪单个祖细胞谱系的现代技术为决定大脑细胞命运的过程提供了一些线索，也让我们了解了克隆相关细胞的迁移模式。在中枢神经系统的许多部位，祖细胞具有多能性；单个克隆可以包含多种神经元类型，甚至是神经元和神经胶质细胞的混合物。此外，即使在狭窄的时间窗口内进行标记，也能观察到克隆大小的广泛分布。这表明祖细胞可能具有相当的可塑性，并对环境信号做出反应。在发育中的皮层中，克隆相关细胞最初彼此相邻聚集，就像在视网膜和视顶盖中一样。然而，这些细胞随后沿着胶质纤维从脑室区迁移到皮层的过程中，克隆相关神经元会逐渐分散。
