Georgitis J W, Szefler S J, Baswell B, Shen D D
Ann Allergy. 1984 Sep;53(3):231-5.
Assessment of individual pharmacokinetics has been helpful in the evaluation of patients with persistently low serum theophylline concentrations and poorly controlled asthma. This paper presents seven cases where pharmacokinetic profiling specifically identified the etiology for low theophylline concentrations. Pharmacokinetic profiles were done following oral or intravenous dosing of theophylline. Serial blood samples drawn over 12 hours were assayed for theophylline concentrations using HPLC. Serum half-life (t1/2), clearance (Cl), volume of distribution (VD) and time-to-peak concentration were determined for each subject. In this series, three patients exhibited rapid theophylline clearance, two had predictable theophylline pharmacokinetics, and two presented with unique pharmacokinetics. These cases illustrate a wide range of pharmacokinetic behavior seen in clinical practice. To evaluate patients with persistently subtherapeutic theophylline concentrations, determination of individual pharmacokinetic profiles should be performed before prescribing high doses of theophylline (greater than 30 mg/kg/day).
对个体药代动力学的评估有助于对血清茶碱浓度持续偏低且哮喘控制不佳的患者进行评估。本文介绍了7例药代动力学分析明确了茶碱浓度偏低病因的病例。在口服或静脉注射茶碱后进行药代动力学分析。使用高效液相色谱法（HPLC）测定在12小时内采集的系列血样中的茶碱浓度。测定每个受试者的血清半衰期（t1/2）、清除率（Cl）、分布容积（VD）和达峰时间。在该系列中，3例患者表现出茶碱快速清除，2例具有可预测的茶碱药代动力学，2例呈现出独特的药代动力学。这些病例说明了临床实践中所见的广泛药代动力学行为。为评估茶碱浓度持续低于治疗水平的患者，在开具高剂量茶碱（大于30mg/kg/天）之前应进行个体药代动力学分析。
