Leeder J S, Robertson C, Correia J, Isles A F, Levison H, Macleod S M
Ann Allergy. 1986 Feb;56(2):133-7.
A sustained-release theophylline preparation (Theo-Dur Sprinkle) was evaluated in young asthmatic patients aged 1 to 6 years and receiving a daily dose of 23.4 +/- 2.0 mg/kg (mean +/- SD) to determine, on the basis of serial serum concentrations obtained over a 12-hour dosing interval at steady state, the suitability of such a product in patients likely to metabolize the drug very rapidly. Peak theophylline concentrations of 15.1 +/- 4.1 mg/L were achieved 5.5 +/- 1.5 hours after dosing. The mean maximum to minimum concentration difference was 6.9 +/- 2.2 mg/L for the dosing interval studied. Fluctuations in theophylline concentration less than 100% were achieved in nine of the 12 study patients. Use of the "sprinkle-technique" with Theo-Dur Sprinkle appears to be a simple and effective method of maintaining acceptable fluctuations in serum theophylline concentrations in preschool asthmatic children.
对一种缓释茶碱制剂（Theo-Dur Sprinkle）进行了评估，该制剂用于1至6岁的年轻哮喘患者，他们每日剂量为23.4±2.0毫克/千克（平均值±标准差）。基于在稳态下12小时给药间隔内获得的系列血清浓度，以确定这种产品对可能非常快速代谢该药物的患者的适用性。给药后5.5±1.5小时达到的茶碱峰值浓度为15.1±4.1毫克/升。在所研究的给药间隔内，平均最大与最小浓度差为6.9±2.2毫克/升。12名研究患者中有9名实现了茶碱浓度波动小于100%。使用Theo-Dur Sprinkle的“撒播技术”似乎是维持学龄前哮喘儿童血清茶碱浓度波动在可接受范围内的一种简单有效的方法。
