Laurent J, Heslan J M, Branellec A, Lagrue G
Ann Biol Clin (Paris). 1984;42(3):207-10.
Con A stimulated lymphocytes from some patients with primary glomerular disease release in vitro a lymphokine, the vascular permeability factor (VPF). House dust sensitization was early reported among these patients. We therefore studied the action of this specific mitogen on VPF production in 58 patients with primary glomerular disease, whose 23 chosen because cutaneous house dust sensitivity. For the whole patients, house dust and Con A induced VPF production were statistically equivalent and both higher than that of unstimulated lymphocytes. Lymphocytes from the 23 house dust sensitised patients, stimulated by the allergen, produced more VPF than lymphocytes from unsensitised patients.
刀豆蛋白A刺激一些原发性肾小球疾病患者的淋巴细胞在体外释放一种淋巴因子，即血管通透性因子（VPF）。这些患者中早期就有报道对屋尘敏感。因此，我们研究了这种特异性促细胞分裂剂对58例原发性肾小球疾病患者VPF产生的作用，其中23例因对屋尘皮肤过敏而入选。对于所有患者，屋尘和刀豆蛋白A诱导的VPF产生在统计学上相当，且均高于未刺激的淋巴细胞。23例对屋尘敏感患者的淋巴细胞在变应原刺激下产生的VPF比未致敏患者的淋巴细胞更多。
