Stieglitz P, Jacquot C
Ann Fr Anesth Reanim. 1984;3(4):318-21. doi: 10.1016/s0750-7658(84)80129-x.
Gaseous anaesthetic pollution in operating theatres has been known since as far back as 1924. Following Vaisman and Cohen's epidemiology studies, health organizations have been involved in this professional concern. Halogenated vapours and nitrous oxide anaesthetic pollution have been accused of doubling the abortion rate and of moderately increasing the number of congenital abnormalities in the offsprings of anaesthetists. The liver and nervous system are also likely targets for anaesthetic pollution. Animal or cell culture experimental studies concerning pathological consequences of exposure to nitrous oxide or halogenated vapours give conflicting results and are not conclusive. The pollution rate is measured by chromatography and spectrophotometry. 25 ppm nitrous oxide and 2 ppm halothane are the upper limits allowed for air contamination. Total intravenous anaesthesia, closed circuits, draining away expired gases can prevent such pollution, but these techniques do have drawbacks. Pollution prevention is rather simple, moderately expensive and comforting for operating room staff.
早在1924年人们就已经知晓手术室中的气态麻醉剂污染问题。继维斯曼和科恩的流行病学研究之后,卫生组织也参与到了这一专业关注领域。卤化蒸汽和一氧化二氮麻醉剂污染被指控使流产率翻倍,并适度增加麻醉师后代先天性异常的数量。肝脏和神经系统也可能是麻醉剂污染的目标。关于接触一氧化二氮或卤化蒸汽的病理后果的动物或细胞培养实验研究结果相互矛盾,尚无定论。污染率通过色谱法和分光光度法测量。一氧化二氮25 ppm和氟烷2 ppm是空气污染允许的上限。全静脉麻醉、闭路循环、排出呼出气体可以防止此类污染,但这些技术确实存在缺点。预防污染相当简单,成本适中,对手术室工作人员来说也令人安心。