Busbee D L, Guyden J, Kingston T, Rose F L, Cantrell E T
Cancer Lett. 1978 Feb;4(2):61-7. doi: 10.1016/s0304-3835(78)93467-5.
Ambystoma tigrinum found in a sewage polluted pond had high levels of aryl hydrocarbon hydroxylase (AHH) activity that decreased to the basal level of control animals after being held several months in clean water. The qualitative formation of benzo(a)pyrene (BP) metabolites by salamander hepatic microsomes was similar to those seen for other species. Inhibition of epoxide hydrase activity did not alter the total metabolite production but did change the ratio of metabolites. A correlation appears to exist between high AHH induction, the presence of polycyclic hydrocarbon pollutants, and the high rate of spontaneous cancer in salamanders.
在一个受污水污染的池塘中发现的虎纹钝口螈具有高水平的芳烃羟化酶（AHH）活性，在清洁水中饲养几个月后，该活性降至对照动物的基础水平。蝾螈肝脏微粒体对苯并（a）芘（BP）代谢物的定性形成与其他物种相似。环氧水解酶活性的抑制并未改变代谢物的总产量，但确实改变了代谢物的比例。高AHH诱导、多环烃污染物的存在与蝾螈的高自发癌发生率之间似乎存在相关性。
