Reddy B S, Hedges A, Laakso K, Wynder E L
Cancer Lett. 1978 Apr;4(4):217-22. doi: 10.1016/s0304-3835(78)94622-0.
Feces collected in Kuopio, Finland, a low-risk population for colon cancer, and in the New York metropolitan area, a high-risk population for colon cancer, were compared. The dietary intake of fat and protein were the same in the two populations, but the sources of fat were different, a greater portion coming from meat in New York, and from dairy products in Kuopio. The daily stool output was higher in Kuopio due to the high intake of cereal products rich in fiber. The concentration of fecal secondary bile acids and the bacterial beta-glucuronidase activity were lower in Kuopio, but the daily output of these constituents was the same in the two groups. The daily fecal excretion of neutral sterols was higher in Kuopio than in New York. Our data suggest that the greater fecal bulk in Kuopio may dilute tumorigenic compounds which come in direct contact with the colon mucosa.
对芬兰库奥皮奥（结肠癌低风险人群）和纽约大都市地区（结肠癌高风险人群）收集的粪便进行了比较。这两个人群的脂肪和蛋白质饮食摄入量相同，但脂肪来源不同，纽约人群中更大比例的脂肪来自肉类，而库奥皮奥人群中则来自乳制品。由于富含纤维的谷物产品摄入量高，库奥皮奥的每日粪便排出量更高。库奥皮奥的粪便次级胆汁酸浓度和细菌β-葡萄糖醛酸酶活性较低，但两组中这些成分的每日排出量相同。库奥皮奥中性固醇的每日粪便排泄量高于纽约。我们的数据表明，库奥皮奥更大的粪便量可能会稀释与结肠黏膜直接接触的致癌化合物。
