Domellof L, Darby L, Hanson D, Mathews L, Simi B, Reddy B S
Nutr Cancer. 1982;4(2):120-7. doi: 10.1080/01635588209513747.
The dietary pattern, fecal bile acid and neutral sterol concentrations, and the bacterial beta-glucuronidase activity of 2 population groups with a varied risk for colon cancer development (i.e., a high-risk population in the metropolitan New York area and an intermediate-risk population in Umea, Sweden) were investigated. The average daily intake of dietary protein was the same in the 2 groups, but the fat intake was higher in Umea than in New York. The daily total fiber intake was also higher in Umea, as was the daily total stool output. The concentration of fecal secondary bile acids and beta-glucuronidase activity was lower in Umea than in New York, but the total daily excretion of these constituents was the same in both groups. The data suggest that one of the factors contributing to the lower risk of colon cancer in Umea, despite the high dietary fat intake, is the high intake of dietary whole grain and cereal fiber, which leads to an increase in stool bulk, thus diluting and/or binding promoters.
对两组患结肠癌风险不同的人群（即纽约大都市地区的高风险人群和瑞典于默奥的中度风险人群）的饮食模式、粪便胆汁酸和中性固醇浓度以及细菌β-葡萄糖醛酸酶活性进行了调查。两组的每日膳食蛋白质平均摄入量相同，但于默奥的脂肪摄入量高于纽约。于默奥的每日膳食纤维总摄入量也更高，每日粪便总量也是如此。于默奥的粪便次级胆汁酸浓度和β-葡萄糖醛酸酶活性低于纽约，但两组这些成分的每日总排泄量相同。数据表明，尽管于默奥的膳食脂肪摄入量较高，但结肠癌风险较低的一个因素是全谷物和谷类纤维的高摄入量，这会导致粪便量增加，从而稀释和/或结合致癌物。
