Zachariah S
Ann Ophthalmol. 1984 Jul;16(7):672-4.
Twenty-five human subjects of both sexes undergoing operations for senile cataract were selected for the present study. Doxycycline was administered orally and at various intervals its penetration into the serum and aqueous humor were determined. It was concluded that for achieving therapeutic concentrations in the serum, doxycycline can be given in the dosage of 200 mg on the first day followed by 100 mg every 24 hours. However, in order to achieve therapeutic concentrations in the aqueous humor, doxycycline should be administered in the dosage of 200 mg on the first day followed by 100 mg every 12 hours.
本研究选取了25名接受老年性白内障手术的男女受试者。口服强力霉素，并在不同时间间隔测定其在血清和房水中的渗透情况。得出的结论是，为了在血清中达到治疗浓度，强力霉素首日剂量可为200毫克，之后每24小时100毫克。然而，为了在房水中达到治疗浓度，强力霉素首日剂量应为200毫克，之后每12小时100毫克。
