苯并(a)蒽-3,4-二醇-1,2-环氧化物是小鼠皮肤终极致癌物的证据。 - Suppr

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超能文献

Evidence that benzo(a)anthracene 3,4-diol-1,2-epoxide is an ultimate carcinogen on mouse skin.

作者信息

Levin W, Thakker D R, Wood A W, Chang R L, Lehr R E, Jerina D M, Conney A H

出版信息

Cancer Res. 1978 Jun;38(6):1705-10.

PMID:647681

Abstract

摘要

相似文献

Evidence that benzo(a)anthracene 3,4-diol-1,2-epoxide is an ultimate carcinogen on mouse skin.苯并(a)蒽-3,4-二醇-1,2-环氧化物是小鼠皮肤终极致癌物的证据。

Cancer Res. 1978 Jun;38(6):1705-10.

Potent tumor-initiating activity of the 3,4-dihydrodiol of 7,12-dimethylbenz(a)anthracene in mouse skin.7,12-二甲基苯并(a)蒽的3,4-二氢二醇在小鼠皮肤中的强效肿瘤起始活性。

Cancer Res. 1979 Jun;39(6 Pt 1):1934-6.

High stereoselectivity among the optical isomers of the diastereomeric bay-region diol-epoxides of benz(a)anthracene in the expression of tumorigenic activity in murine tumor models.苯并(a)蒽的非对映体湾区二醇环氧化物的光学异构体在小鼠肿瘤模型中致瘤活性表达方面具有高度立体选择性。

Cancer Res. 1984 Mar;44(3):929-33.

Tumorigenicity of the dihydrodiols of dibenzo(a,h)anthracene on mouse skin and in newborn mice.二苯并(a,h)蒽二氢二醇对小鼠皮肤及新生小鼠的致瘤性

Cancer Res. 1979 Apr;39(4):1310-4.

Mouse skin tumor-initiating activity of 5-, 7-, and 12-methyl- and fluorine-substituted benz[a]anthracenes.5-、7-和12-甲基及氟取代苯并[a]蒽的小鼠皮肤肿瘤起始活性。

J Natl Cancer Inst. 1982 Sep;69(3):725-8.

Carcinogenicity and mutagenicity of benz(a)anthracene diols and diol-epoxides.苯并(a)蒽二醇及二醇环氧化物的致癌性和致突变性。

Cancer Res. 1978 Jun;38(6):1699-704.

Marked differences in the skin tumor-initiating activities of the optical enantiomers of the diastereomeric benzo(a)pyrene 7,8-diol-9,10-epoxides.非对映体苯并(a)芘7,8-二醇-9,10-环氧化物的旋光对映体在皮肤肿瘤起始活性方面存在显著差异。

Cancer Res. 1979 Jan;39(1):67-71.

Mutagenicity and tumor-initiating activity of fluorinated derivatives of 7,12-dimethylbenz(a)anthracene.7,12-二甲基苯并(a)蒽的氟化衍生物的致突变性和肿瘤起始活性。

Cancer Res. 1979 Feb;39(2 Pt 1):411-4.

Inhibition of 7-bromomethylbenz[a]anthracene-promoted mouse skin tumor formation by retinoic acid and dexamethasone.维甲酸和地塞米松对7-溴甲基苯并[a]蒽促进的小鼠皮肤肿瘤形成的抑制作用。

Cancer Res. 1983 Jul;43(7):3045-9.

Carcinogenicity and mutagenicity of the 3,4-dihydrodiols and other metabolites of 7,12-dimethylbenz(a)anthracene and its hydroxymethyl derivatives.7,12-二甲基苯并(a)蒽及其羟甲基衍生物的3,4-二氢二醇和其他代谢产物的致癌性和致突变性。

Cancer Res. 1980 Oct;40(10):3661-4.

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Polycyclic aromatic hydrocarbons and possible metabolites: convertogenic activity in yeast and tumor initiating activity in mouse skin.多环芳烃及其可能的代谢产物：在酵母中的转化活性及在小鼠皮肤中的肿瘤起始活性。

J Cancer Res Clin Oncol. 1981;102(2):127-39. doi: 10.1007/BF00410664.

Epoxidation reactions catalyzed by rat liver cytochromes P-450 and P-448 occur at different faces of the 8,9-double bond of 8-methylbenz[a]anthracene.大鼠肝细胞色素P-450和P-448催化的环氧化反应发生在8-甲基苯并[a]蒽的8,9-双键的不同面上。

Proc Natl Acad Sci U S A. 1982 Nov;79(22):6802-6. doi: 10.1073/pnas.79.22.6802.

Specificity of chemiluminescence in the metabolism of benzo[a]pyrene to its carcinogenic diol epoxide.苯并[a]芘代谢为其致癌二醇环氧化物过程中化学发光的特异性。

Proc Natl Acad Sci U S A. 1981 Feb;78(2):940-2. doi: 10.1073/pnas.78.2.940.

Identification and determination of urinary metabolites of 2-isopropylnaphthalene in rabbits.兔体内2-异丙基萘尿液代谢物的鉴定与测定

Eur J Drug Metab Pharmacokinet. 1987 Jan-Mar;12(1):11-6. doi: 10.1007/BF03189856.

Role of diaxial versus diequatorial hydroxyl groups in the tumorigenic activity of a benzo[a]pyrene bay-region diol epoxide.苯并[a]芘湾区二醇环氧化物致瘤活性中双轴羟基与双赤道羟基的作用。

Proc Natl Acad Sci U S A. 1987 Dec;84(23):8633-6. doi: 10.1073/pnas.84.23.8633.

Comparison of mutagenesis and malignant transformation by dihydrodiols from benz[a]anthracene and 7,12-dimethylbenz[a]anthracene.苯并[a]蒽和7,12-二甲基苯并[a]蒽的二氢二醇的诱变作用与恶性转化的比较。

Br J Cancer. 1979 May;39(5):540-7. doi: 10.1038/bjc.1979.99.

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