茶碱剂量预测
Theophylline dose prediction.
作者信息
Beswick D T, Cullen R E, Rylance G W
出版信息
Arch Dis Child. 1984 Aug;59(8):758-61. doi: 10.1136/adc.59.8.758.
Two methods of predicting the optimal dose of theophylline in children aged 2 to 13 years were assessed. The observed plasma concentration was within 95% confidence limits of that predicted on eight of 14 occasions using a traditional multiple point pharmacokinetic method. Using a nomogram derived from the plasma concentration 6 hours after dosing and the logarithm of the calculated dose, which were significantly correlated, there was a significant relation between the dose predicted and the actual dose required to produce a concentration of 55 mumol/l.
评估了两种预测2至13岁儿童茶碱最佳剂量的方法。使用传统的多点药代动力学方法，在14次中有8次观察到的血浆浓度在预测浓度的95%置信区间内。使用根据给药后6小时的血浆浓度和计算剂量的对数得出的列线图（两者显著相关），预测剂量与产生55μmol/L浓度所需的实际剂量之间存在显著关系。
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