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[性成熟小鼠正常肝脏和再生肝脏中的集落形成单位]

[CFUs of the normal and regenerating liver in the sexually mature mouse].

作者信息

Starostin V I, Sokolova E A, Turdyev A A

出版信息

Arkh Anat Gistol Embriol. 1984 Jun;86(6):36-42.

PMID:6477148
Abstract

Functional properties of CFUs have been studied in intact and regenerating liver of mice. According to a number of properties (proliferative activity, character of colony growth) CFUs in the liver are similar to CFUs in the peripheral blood and, probably, make the same population. In the regenerating liver relative contents of CFUs 3-5 days after a partial resection is substantially increasing. Concentration of CFUs (endogenic) increases significantly also in a locally injured and regenerating lobe, comparing to the intact lobe that is in the same organ. The transplanted bone marrow CFUs prevail in number in the regenerating liver over the intact liver. It is concluded that increasing contents of CFUs in the regenerating liver depend mainly on its creased property to invade and/or to hold the extrahepatic CFUs.

摘要

已在完整的和再生的小鼠肝脏中研究了集落形成单位(CFU)的功能特性。根据一些特性(增殖活性、集落生长特征),肝脏中的CFU与外周血中的CFU相似,并且可能属于同一群体。部分切除术后3至5天,再生肝脏中CFU的相对含量大幅增加。与同一器官中的完整叶相比,局部损伤和再生叶中CFU(内源性)的浓度也显著增加。在再生肝脏中,移植的骨髓CFU在数量上比完整肝脏中的占优势。得出的结论是,再生肝脏中CFU含量的增加主要取决于其增加的侵入和/或保留肝外CFU的特性。

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