Bell J A, Feldon S E
Arch Ophthalmol. 1984 Sep;102(9):1294-8. doi: 10.1001/archopht.1984.01040031044020.
The capillary perfusion of 14 eyes with nonproliferative diabetic retinopathy and 14 eyes with retinal branch vein occlusion was assessed by wide-angle fluorescein angiography. Regional perfusion was directly correlated with visual sensitivity determined by OCTOPUS-automated static perimetry. Visual function was found to correlate linearly with capillary perfusion in both diseases. Occasional foci of decreased visual sensitivity that corresponded to a region of good capillary perfusion were found in the central fields of diabetics. Although capillary dropout appears to be the major cause of decreased visual sensitivity in microangiopathy, local metabolic factors may also play a role. Further studies are required to determine whether foci of decreased function are predictive of future capillary dropout or neovascularization.
通过广角荧光素血管造影术评估了14例非增殖性糖尿病视网膜病变患者的14只眼和14例视网膜分支静脉阻塞患者的14只眼的毛细血管灌注情况。局部灌注与通过OCTOPUS自动静态视野计测定的视觉敏感度直接相关。发现在这两种疾病中视觉功能均与毛细血管灌注呈线性相关。在糖尿病患者的中心视野中发现了偶尔出现的视觉敏感度降低的病灶，这些病灶对应于毛细血管灌注良好的区域。尽管毛细血管缺失似乎是微血管病变中视觉敏感度降低的主要原因，但局部代谢因素可能也起作用。需要进一步研究以确定功能降低的病灶是否可预测未来的毛细血管缺失或新生血管形成。
