Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, 606-8507, Japan.
Graefes Arch Clin Exp Ophthalmol. 2012 May;250(5):635-44. doi: 10.1007/s00417-011-1860-0. Epub 2011 Nov 18.
To study the correlation of retinal sensitivity with both morphologic changes in the macula and status of retinal capillary perfusion, after resolution of the macular edema associated with retinal vein occlusion (RVO).
Retinal sensitivity in the macular area was examined with the Micro Perimeter 1 in 24 eyes after resolution of the macular edema associated with RVO. Using spectral-domain optical coherence tomography, 6 mm × 6 mm areas of macula were examined with 256 sequential horizontal scans. Condition of the photoreceptor layer was evaluated depending upon detection of the junctions between inner and outer segments of the photoreceptors (IS/OS). Fluorescein angiography was performed in 19 eyes.
Mean retinal sensitivity on the affected side of the retina was significantly decreased (p < 0.001). On the affected side, the mean retinal sensitivity within the area of deteriorated IS/OS was significantly less (3.8 ± 4.8 dB) than that within areas with complete IS/OS (10.1 ± 6.4 dB, p < 0.001). Mean retinal sensitivity within nonperfused areas was extremely low (0.3 ± 1.3 dB), compared with that in perfused retina (10.9 ± 5.9 dB, p < 0.001). In eyes with a broken foveal capillary ring (FCR), the marked decline in retinal sensitivity was seen within the area where the FCR was broken; this was not seen in eyes with an intact FCR.
Retinal function was decreased markedly in areas with a damaged photoreceptor layer due to RVO, and was lethally decreased within nonperfused areas. Due to the various limitations of the current study, including implementation of fluorescein angiography in limited number of eyes, wide range of follow-up, and heterogeneity of pretreatments, further prospective studies are necessary to confirm the current findings.
研究视网膜静脉阻塞（RVO）相关黄斑水肿消退后视网膜敏感性与黄斑形态改变和视网膜毛细血管灌注状态的相关性。
用微视野计 1 检查 24 只眼的黄斑区视网膜敏感性。采用频域光相干断层扫描，对 6mm×6mm 黄斑区进行 256 次连续水平扫描。根据检测到的内、外节光感受器（IS/OS）交界处来评估光感受器层的状态。对 19 只眼进行荧光素血管造影。
受影响侧视网膜的平均视网膜敏感性显著降低（p<0.001）。在受影响侧，IS/OS 恶化区域的平均视网膜敏感性（3.8±4.8dB）明显低于 IS/OS 完整区域（10.1±6.4dB，p<0.001）。无灌注区域的平均视网膜敏感性极低（0.3±1.3dB），与灌注视网膜（10.9±5.9dB，p<0.001）相比差异有统计学意义。在有 FCR 断裂的眼中，FCR 断裂区域的视网膜敏感性明显下降；而在有完整 FCR 的眼中则没有这种情况。
由于 RVO 导致光感受器层受损，受影响区域的视网膜功能明显下降，在无灌注区域则严重下降。由于目前的研究存在各种局限性，包括荧光素血管造影在有限数量的眼中实施、随访范围广泛和预处理的异质性，需要进一步的前瞻性研究来证实目前的发现。
