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动脉瘤模型中脉动血流及颗粒路径的计算

Calculation of pulsatile flow and particle paths in an aneurysm-model.

作者信息

Perktold K, Gruber K, Kenner T, Florian H

出版信息

Basic Res Cardiol. 1984 May-Jun;79(3):253-61. doi: 10.1007/BF01908024.

DOI:10.1007/BF01908024
PMID:6477378
Abstract

The velocity field and the wall shear stress have been calculated numerically by the finite element method to the time-dependent Navier-Stokes equations for pulsatile flow in a model of an aneurysm. The results show a complex flow field with two eddies growing and disappearing during the cardiac cycle. Downstream at the outlet vessel high wall shear stress occurs, which may lead to a downstream-growing of the aneurysm. With the knowledge of a sufficiently accurate flow field, the calculation of several particle paths has been carried out. Starting points and starting time are varied. The paths demonstrate the time-dependent development, shift and disappearance of vortices during the pulsatile cycle and provide hints on zones of stasis. These are significant factors in thrombogenesis.

摘要

通过有限元方法对动脉瘤模型中脉动流的时间相关纳维-斯托克斯方程进行了数值计算,得出了速度场和壁面剪应力。结果显示了一个复杂的流场,在心动周期中有两个涡流生长和消失。在出口血管下游出现高壁面剪应力,这可能导致动脉瘤向下游生长。在已知足够精确的流场的情况下,进行了几条粒子路径的计算。起点和起始时间是变化的。这些路径展示了脉动周期中涡流随时间的发展、移动和消失,并提供了关于停滞区域的线索。这些是血栓形成的重要因素。

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Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin.前列腺素内过氧化物、血栓素A2和前列环素的药理学及内源性作用。
Pharmacol Rev. 1978 Sep;30(3):293-331.
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AJNR Am J Neuroradiol. 2003 Apr;24(4):597-603.
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Experimental model of dissecting aneurysms.夹层动脉瘤的实验模型
AJNR Am J Neuroradiol. 2002 Apr;23(4):577-84.
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AJNR Am J Neuroradiol. 1999 May;20(5):807-11.
7
Haemodynamic stress in lateral saccular aneurysms. An experimental study.外侧囊状动脉瘤的血流动力学应激。一项实验研究。
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