Pathak D N, Roy D, Singh R
Biochem Int. 1984 Jul;9(1):59-68.
GABA-transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSA-DH) activities were measured in the mitochondrial fractions from the cobalt- and FeCl3-induced chronic epileptogenic foci in the rat brain. Electroencephalographically, the FeCl3 epileptogenic focus remained active for a duration longer than that of the cobalt focus. In both the foci SSA-DH activity showed significant increases which were concomitant with the EEG epileptiform activity. In cobalt focus, the GABA-T activity fell whereas, in the FeCl3 focus it was unchanged. In cobalt focus fall in GABA-T activity seemed to be concomitant with EEG epileptiform discharge. The measurements of the enzyme activities in the mirror (secondary) foci showed that, except for a brief stimulation of SSA-DH activity in the mirror focus in FeCl3 epileptic animals, the enzyme activities remained unchanged. Possible significance of the observed enzymatic changes in the physiology of epileptogenic focus is discussed.
在大鼠大脑中，对钴和氯化铁诱导的慢性致痫灶线粒体部分的γ-氨基丁酸转氨酶（GABA-T）和琥珀酸半醛脱氢酶（SSA-DH）活性进行了测定。脑电图显示，氯化铁致痫灶的活跃持续时间比钴致痫灶更长。在这两种致痫灶中，SSA-DH活性均显著增加，且与脑电图癫痫样活动同时出现。在钴致痫灶中，GABA-T活性下降，而在氯化铁致痫灶中则保持不变。在钴致痫灶中，GABA-T活性下降似乎与脑电图癫痫样放电同时出现。在镜像（继发性）致痫灶中的酶活性测量结果表明，除了在氯化铁癫痫动物的镜像致痫灶中SSA-DH活性有短暂刺激外，酶活性保持不变。文中讨论了在致痫灶生理学中观察到的酶变化的可能意义。
