McAvinchey D J, McCollum P T, Lynch G
Br J Surg. 1984 Sep;71(9):715-7. doi: 10.1002/bjs.1800710925.
Peritoneal infection progresses through defined stages: contamination, inflammation and abscess formation. An experimental model of established peritonitis without adjuvant in the rat was used to test the effect of various local and systemic agents on survival. There was significant improvement in all treatment groups except those treated with antiseptic lavage using PVP-I and noxythiolin. Intramuscular ampicillin improved survival from 40 to 60 per cent while intramuscular amikacin combined with local irrigation with metronidazole reduced mortality to nil (P less than 0.001). Both cephradine and metronidazole used as peritoneal lavage solutions improved survival (P less than 0.005) when compared with the controls but the difference was not significant when compared with irrigation with Hartmann's solution. Metronidazole given rectally also improved survival from 40 to 60 per cent but this difference was not significant. We conclude that survival in established peritonitis depends upon adequate antibiotic therapy.
污染、炎症和脓肿形成。使用大鼠无佐剂的既定腹膜炎实验模型来测试各种局部和全身药物对存活率的影响。除使用聚维酮碘和硝噻唑啉进行防腐灌洗的治疗组外，所有治疗组均有显著改善。肌肉注射氨苄西林使存活率从40%提高到60%，而肌肉注射阿米卡星联合局部用甲硝唑冲洗可将死亡率降至零（P小于0.001）。与对照组相比，头孢拉定和甲硝唑用作腹膜灌洗溶液时均提高了存活率（P小于0.005），但与用哈特曼溶液冲洗相比，差异不显著。直肠给予甲硝唑也使存活率从40%提高到60%，但这种差异不显著。我们得出结论，既定腹膜炎的存活率取决于充分的抗生素治疗。
