Gilmore O J, Reid C
Br J Surg. 1979 Mar;66(3):197-9. doi: 10.1002/bjs.1800660318.
Peritoneal adhesions were induced in 250 female Wistar rats by the excision and closure of a right lower quadrant parietal peritoneal defect. After closure of the defect each rat was randomly allocated to one of five treatment groups: A, control with no instillate; B, control with Ringer solution; C, noxythiolin 0.5 per cent solution; D, noxythiolin 1 per cent solution; E povidone-iodine/PVP solution. Two millilitres of the appropriate solution were injected into the peritoneal cavity just before closure of a standard 4-cm midline incision. Assessment of adhesion formation was made at 1 week in ignorance of the treatment group. Noxythiolin 1 per cent was more effective than Ringer solution and noxythiolin 0.5 per cent in reducing the mean number of adhesions (P less than 0.05) but was inferior to povidone-iodine/PVP (P less than 0.05). Povidone-iodine/PVP solution significantly reduced the number of adhesions compared with the four other groups. In addition, it significantly reduced the mean length of attachment of each adhesion compared with the two control groups (P less than 0.001).
通过切除并闭合右下象限的腹壁腹膜缺损，在250只雌性Wistar大鼠中诱导形成腹膜粘连。缺损闭合后，将每只大鼠随机分配到五个治疗组之一：A组，不注入任何液体作为对照；B组，注入林格液作为对照；C组，注入0.5%的诺氟沙星溶液；D组，注入1%的诺氟沙星溶液；E组，注入聚维酮碘/聚乙烯吡咯烷酮溶液。在缝合标准的4厘米中线切口前，向腹腔内注入2毫升相应的溶液。在不知道治疗组的情况下，于1周时评估粘连形成情况。1%的诺氟沙星在减少粘连平均数量方面比林格液和0.5%的诺氟沙星更有效（P<0.05），但不如聚维酮碘/聚乙烯吡咯烷酮（P<0.05）。与其他四组相比，聚维酮碘/聚乙烯吡咯烷酮溶液显著减少了粘连数量。此外，与两个对照组相比，它还显著缩短了每个粘连的附着平均长度（P<0.001）。
