Dwyer B E, Wasterlain C G
Brain Res. 1984 Aug 6;308(1):109-21. doi: 10.1016/0006-8993(84)90922-3.
Generalized epileptic seizures, induced in 5-7 day-old marmoset monkeys with bicuculline (5 mg/kg) produce striking focal disruption of protein synthesis. Inhibition of protein synthesis was most severe in the neocortex and hippocampus but was completely absent in the lateral geniculate nuclei and in the optic tract. In the cortex, regions in which protein synthesis was most severely reduced alternated with areas in which it was relatively preserved creating a columnar pattern. With few exceptions, subcortical gray matter structures in the forebrain and brainstem were less severely affected than the cortex. In the cerebellum, seizures appeared to have little effect on the proliferating external granular layer while the closely adjacent internal granular layer showed clear-cut inhibition. The focal nature of protein synthesis inhibition in brain during seizures suggests that the systemic effects of convulsions (e.g. hypoxemia, acidosis or changes in arterial blood pressure) are not a major factor. More likely, protein synthesis inhibition is related to the extent to which various cerebral structures participate in seizure activity.
用荷包牡丹碱（5毫克/千克）诱导5 - 7日龄狨猴发生全身性癫痫发作，会导致蛋白质合成出现明显的局灶性破坏。蛋白质合成抑制在新皮层和海马体中最为严重，但在外侧膝状体核和视束中则完全不存在。在皮层中，蛋白质合成严重减少的区域与相对保留的区域交替出现，形成柱状模式。几乎无一例外，前脑和脑干中的皮层下灰质结构受影响的程度比皮层轻。在小脑中，癫痫发作似乎对增殖的外颗粒层影响很小，而紧邻的内颗粒层则表现出明显的抑制。癫痫发作期间大脑中蛋白质合成抑制的局灶性表明，惊厥的全身性影响（如低氧血症、酸中毒或动脉血压变化）不是主要因素。更有可能的是，蛋白质合成抑制与各种脑结构参与癫痫活动的程度有关。
