Mangiapane M L, Thrasher T N, Keil L C, Simpson J B, Ganong W F
Brain Res Bull. 1984 Jul;13(1):43-7. doi: 10.1016/0361-9230(84)90006-6.
The effect of subfornical organ (SFO) lesions on plasma vasopressin and drinking was tested in rats given either of two stimuli: subcutaneous injection of hypertonic saline or injection of a single dose of angiotensin II (AII) into the dorsal third cerebral ventricle. Drinking in response to hypertonicity was significantly attenuated, whereas AII-induced drinking was unaffected by the lesions. In contrast, SFO lesions were associated with significantly reduced vasopressin responses following either of these potent stimuli to vasopressin secretion. Partial lesions that damaged structures adjoining the SFO (fornix or septum) had no significant effects. These results demonstrate that, in rats, the SFO is in some way necessary for vasopressin responses to both AII and hypertonicity.
在给予两种刺激之一的大鼠中，测试了穹窿下器（SFO）损伤对血浆血管加压素和饮水的影响：皮下注射高渗盐水或向第三脑室背侧注射单剂量血管紧张素II（AII）。对高渗性的饮水反应明显减弱，而AII诱导的饮水不受损伤影响。相反，在这两种对血管加压素分泌的有效刺激后，SFO损伤与血管加压素反应显著降低有关。损伤毗邻SFO的结构（穹窿或隔膜）的部分损伤没有显著影响。这些结果表明，在大鼠中，SFO在某种程度上是血管加压素对AII和高渗性反应所必需的。
