Lind R W, Thunhorst R L, Johnson A K
Physiol Behav. 1984 Jan;32(1):69-74. doi: 10.1016/0031-9384(84)90072-6.
Rats with lesions centered on the ventral stalk of the subfornical organ (SFO) were used to characterize the participation of this structure in the control of drinking. It is concluded that the SFO does indeed play some minor role in the mediation of drinking following intraventricular injections of angiotensin. Further, it is shown that lesions of the SFO, but not lesions of the adjacent septal-hippocampal tissue, attenuate osmotic thirst elicited by two doses of hypertonic saline. Diminished drinking responses following water deprivation, and normal feeding responses following food deprivation, underscore the importance of the SFO for drinking behavior in general, and an expanded role for the SFO in fluid regulation is suggested. However, some incidental observations suggest that the SFO is less than an equal partner with structures in the AV3V region in the overall control of water balance.
以穹窿下器（SFO）腹侧柄为中心发生损伤的大鼠被用于研究该结构在饮水控制中的作用。研究得出结论，在脑室内注射血管紧张素后，SFO确实在饮水调节中发挥了一些次要作用。此外，研究表明，SFO损伤而非相邻的隔区-海马组织损伤，会减弱两剂高渗盐水引起的渗透性口渴。缺水后饮水反应减弱，缺食后正常进食反应，突出了SFO对一般饮水行为的重要性，并提示SFO在液体调节中的作用有所扩展。然而，一些偶然观察结果表明，在总体水平衡控制方面，SFO与第三脑室前腹侧室周区域（AV3V）的结构相比，作用较小。
