Kemeny L J, Wiltsey V L, Riley J L
Cornell Vet. 1975 Jul;65(3):352-62.
Ten breeding sows were left in direct contact with their newborn piglets that had been experimentally infected with transmissible gastroenteritis (TGE) virus. All sows became infected with the virus. The sows developed fever and showed mild clinical signs of the disease for a few days. The sows excreted virus in the nasal secretion, feces, and milk during the acute febrile phase of illness. Virus was isolated from the nasal secretion of one sow as early as 20 hours after contact exposure to the infected piglets. At necropsy, the virus was more frequently isolated from the tissues of the upper respiratory tract than from small intestines; this finding indicated that the TGE coronavirus replicated in the upper respiratory tract and induced an acute respiratory infection in susceptible adult swine. Neutralizing antibody was present in the sera 8 sows after 12 to 36 days during the convalescent period. From these results, we conclude that susceptible sows in direct contact with ill piglets can become infected and by excreting virus can serve as a source of TGE virus for other susceptible pigs on the premises.
十头繁殖母猪与经实验感染传染性胃肠炎（TGE）病毒的新生仔猪直接接触。所有母猪均感染了该病毒。母猪出现发热，并在数天内表现出该病的轻度临床症状。母猪在疾病急性发热期通过鼻分泌物、粪便和乳汁排出病毒。接触感染仔猪后最早在20小时就从一头母猪的鼻分泌物中分离出病毒。尸检时，从上呼吸道组织中比从小肠中更频繁地分离到病毒；这一发现表明TGE冠状病毒在上呼吸道复制，并在易感成年猪中引发急性呼吸道感染。在恢复期，8头母猪的血清在12至36天后出现中和抗体。根据这些结果，我们得出结论，与患病仔猪直接接触的易感母猪可被感染，并通过排出病毒成为场内其他易感猪的TGE病毒来源。
