两名接受达那唑治疗子宫内膜异位症的患者哮喘症状得到缓解。
Relief of asthma in two patients receiving danazol for endometriosis.
作者信息
Pride S M, Yuen B H
出版信息
Can Med Assoc J. 1984 Oct 1;131(7):763-4.
Abstract
This paper describes two patients with endometriosis in whom treatment with danazol resulted in a concomitant remission of asthma. Neither patient reported an association of clinical symptoms with phases of their menstrual cycle. Whether the remission was fortuitous or related to suppression of the activity of the endometriotic tissue or to the ability of danazol to increase the serum levels of two protease inhibitors that are deficient in patients with asthma remains to be determined.
摘要
本文描述了两名患有子宫内膜异位症的患者，她们接受达那唑治疗后哮喘症状同时得到缓解。两名患者均未报告临床症状与月经周期各阶段之间存在关联。这种缓解是偶然发生的，还是与子宫内膜异位组织活性的抑制有关，抑或是与达那唑提高两种哮喘患者体内缺乏的蛋白酶抑制剂血清水平的能力有关，仍有待确定。
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Relief of asthma in two patients receiving danazol for endometriosis.两名接受达那唑治疗子宫内膜异位症的患者哮喘症状得到缓解。
Can Med Assoc J. 1984 Oct 1;131(7):763-4.
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Genetic overlap analysis of endometriosis and asthma identifies shared loci implicating sex hormones and thyroid signalling pathways.子宫内膜异位症和哮喘的遗传重叠分析确定了与性激素和甲状腺信号通路相关的共同位点。
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Relief of asthma with danazol.达那唑缓解哮喘
Can Med Assoc J. 1985 Jan 15;132(2):100.
本文引用的文献
1
Prostaglandin F in human endometriotic tissue.人子宫内膜异位组织中的前列腺素F
Am J Obstet Gynecol. 1981 Oct 1;141(3):344-5. doi: 10.1016/s0002-9378(16)32641-2.
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Circulating immune complexes, complement factors C3, C4, C1-inhibitor, alpha-1-antitrypsin and immunoglobulins in asthmatic patients.哮喘患者体内的循环免疫复合物、补体因子C3、C4、C1抑制剂、α-1抗胰蛋白酶和免疫球蛋白
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Danazol-induced elevation of serum alpha 1-antitrypsin in individuals with severe deficiency of this antiprotease.达那唑可使严重缺乏这种抗蛋白酶的个体血清α1-抗胰蛋白酶水平升高。
Chest. 1980 Feb;77(2 Suppl):279. doi: 10.1378/chest.77.2_supplement.279.
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The concentration of 13,14-dihydro-15-keto prostaglandin F2 alpha and prostaglandin E2 in peritoneal fluid of infertile patients with and without endometriosis.
Fertil Steril. 1982 Aug;38(2):166-70. doi: 10.1016/s0015-0282(16)46453-8.
5
Cul-de-sac fluid in women with endometriosis: fluid volume and prostanoid concentration during the proliferative phase of the cycle--days 8 to 12.患有子宫内膜异位症女性的直肠子宫陷凹积液：月经周期增殖期（第8至12天）的液体量和前列腺素浓度
Fertil Steril. 1982 Jun;37(6):747-50. doi: 10.1016/s0015-0282(16)46332-6.
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Bronchial hyperreactivity to prostaglandin F 2 and histamine in patients with asthma.哮喘患者对前列腺素F2和组胺的支气管高反应性。
Br Med J. 1973 Jan 27;1(5847):193-6. doi: 10.1136/bmj.1.5847.193.
7
Endocrine properties and clinical application of danazol.
Fertil Steril. 1979 Mar;31(3):237-51. doi: 10.1016/s0015-0282(16)43869-0.
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