Häfner G E, Wüthrich B, Grob P J, Arrenbrecht S
Respiration. 1981;41(4):248-57. doi: 10.1159/000194389.
Sera from 159 adult asthmatic outpatients (extrinsic, n = 82, intrinsic, n = 65 and acetylosalicylic acid (ASA)-sensitive, n = 12) and from 100 controls were tested for total levels of IgG, IgM, IgA, IgE, complement factors C3, C4, C1-inhibitor, alpha 1-antitrypsin and circulating immune complexes. The following results were observed: (1) a marked increase of IgE in extrinsic asthma; (2) a slight increase of IgM, and (3) an equal increase of complement C4 levels in all three asthma groups; (4) normal mean values of C3 levels with a significantly larger standard deviation of the mean in all three asthma groups; (5) an equally slight decrease of protease inhibitors, such as C1-inhibitor and alpha 1-antitrypsin, and (6) the presence of circulating immune complexes in 22% of extrinsic, in 8% of intrinsic and 13% of ASA-sensitive asthmatics. Circulating immune complexes can be found in all three asthma groups and may correlate with complement deviation.
对159例成年哮喘门诊患者（外源性哮喘82例、内源性哮喘65例、阿司匹林（ASA）敏感型哮喘12例）以及100例对照者的血清进行检测，分析其中IgG、IgM、IgA、IgE、补体因子C3、C4、C1抑制剂、α1抗胰蛋白酶及循环免疫复合物的总水平。结果如下：（1）外源性哮喘患者IgE显著升高；（2）IgM略有升高；（3）三组哮喘患者补体C4水平均有升高；（4）三组哮喘患者C3水平均值正常，但均值标准差显著增大；（5）蛋白酶抑制剂如C1抑制剂和α1抗胰蛋白酶均略有下降；（6）22%的外源性哮喘患者、8%的内源性哮喘患者及13%的ASA敏感型哮喘患者存在循环免疫复合物。三组哮喘患者均可检测到循环免疫复合物，且可能与补体偏差相关。
