Pines A, Ben-Bassat I, Selzer G, Ramot B
Cancer. 1984 Nov 1;54(9):1904-7. doi: 10.1002/1097-0142(19841101)54:9<1904::aid-cncr2820540921>3.0.co;2-e.
In a woman with chronic lymphocytic leukemia (CLL), a maxillary plasmacytoma developed after 8 years. The membrane-bound immunoglobulin of the leukemic lymphocytes, the cytoplasmic immunoglobulin of the plasma cells, the serum monoclonal protein and the urine Bence-Jones protein had the same heavy and light chains--mu kappa. This suggests that the leukemic cells transformed to plasma cells. This very rare event is a complete reversal of the more common transformation that occurs in CLL and manifested by de-differentiation. Only in one case out of the 20 previously reported patients with CLL and multiple myeloma there was evidence, like in the current case, of a common clonal origin of the two B-cell neoplasms.
在一名患有慢性淋巴细胞白血病（CLL）的女性患者中，8年后出现了上颌浆细胞瘤。白血病淋巴细胞的膜结合免疫球蛋白、浆细胞的胞质免疫球蛋白、血清单克隆蛋白和尿本-周蛋白具有相同的重链和轻链——μκ。这表明白血病细胞转化为了浆细胞。这种非常罕见的事件是CLL中更常见的去分化转化的完全逆转。在先前报道的20例CLL和多发性骨髓瘤患者中，只有1例与当前病例一样，有证据表明这两种B细胞肿瘤有共同的克隆起源。
