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戒酒者和清醒酗酒者脑脊液中的儿茶酚胺及其代谢产物。

Catecholamines and metabolites in cerebrospinal fluid of teetotallers and sober alcoholics.

作者信息

Sjöquist B, Borg S

出版信息

Drug Alcohol Depend. 1984 Jul;13(4):389-94. doi: 10.1016/0376-8716(84)90006-1.

DOI:10.1016/0376-8716(84)90006-1
PMID:6479017
Abstract

Dopamine (DA), homovanillic acid (HVA), salsolinol (SAL), methylated salsolinol (M-SAL), norepinephrine (NE) and 4-hydroxy-3-methoxyphenylglycol (HMPG) were measured in cerebrospinal fluid (CSF) from 8 alcoholics who had abstained from ethanol for 3 months and from 8 teetotallers. No significant differences in the concentrations of any of these catecholamines or their metabolites were found between the two groups. In the alcoholics there was a positive correlation between age and DA (P less than 0.005), NE (P less than 0.025) and SAL (P less than 0.005) and also between DA and SAL (P less than 0.01).

摘要

对8名已戒酒3个月的酗酒者和8名戒酒者的脑脊液(CSF)中的多巴胺(DA)、高香草酸(HVA)、萨索林醇(SAL)、甲基化萨索林醇(M-SAL)、去甲肾上腺素(NE)和4-羟基-3-甲氧基苯乙二醇(HMPG)进行了测量。两组之间这些儿茶酚胺及其代谢产物的浓度均未发现显著差异。在酗酒者中,年龄与DA(P<0.005)、NE(P<0.025)和SAL(P<0.005)之间以及DA与SAL之间(P<0.01)存在正相关。

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