Dittmann V, Pribilla O, Beyer H, Preuss K J
Dtsch Med Wochenschr. 1984 Oct 12;109(41):1557-61. doi: 10.1055/s-2008-1069412.
Eight healthy probands received 1.0 to 1.3 g ethanol per kg body weight within a period of 30 minutes. The average hourly elimination rate of ethanol during the postresorptive phase was found to be 0.18 g/l. No significant increase in the elimination rate was seen either after administration of 200 mg metoprolol per day in slow release form for a period of one week, or after a single dose of 200 mg metoprolol in standard formulation taken at the beginning of ethanol ingestion. On the other hand, long-term administration of metoprolol resulted in a steeper rise and a delayed decrease of blood alcohol concentration. Simultaneous intake of metoprolol and of alcohol in high dosage should be avoided.
八名健康受试者在30分钟内每千克体重摄入1.0至1.3克乙醇。在吸收后阶段，乙醇的平均每小时消除率为0.18克/升。在以缓释形式每天服用200毫克美托洛尔一周后，或者在乙醇摄入开始时服用一剂200毫克标准制剂美托洛尔后，均未观察到消除率有显著增加。另一方面，长期服用美托洛尔会导致血酒精浓度上升更陡且下降延迟。应避免同时高剂量摄入美托洛尔和酒精。
