Lewis L M, Flechtner T W, Kerkay J, Pearson K H, Nakamoto S
Clin Chem. 1978 May;24(5):741-6.
Bis(2-ethylhexyl) phthalate is extracted from artificial kidneys, both in vivo and in vitro. Perfusion of whole blood through arterial-,venous tubing (that supplied with the dialyzer) for 1 h in vitro yielded 3.23 mg of the compound, while similar perfusion of the tubing plus the artificial kidney yielded 6.10 mg. Its mean concentration after dialysis in patients undergoing hemodialysis was 751 microgram/liter of serum. Patients who had undergone more than 50 hemodialysis treatments showed significantly higher postdialysis concentrations than patients who had undergone fewer. Uptake of bis(2-ethylhexyl) phthalate by the blood during a dialysis session followed two patterns. One set of patients showed a maximum concentration at 3 h, the second set showed a steady increase until the end of dialysis. Bis(2-ethylhexyl) phthalate appeared to be rapidly cleared from blood, most being removed within 5 to 7 h of completion of dialysis.
邻苯二甲酸二（2-乙基己基）酯可在体内和体外从人工肾中提取出来。在体外，通过动脉-静脉管路（连接透析器）对全血进行1小时灌注，可产生3.23毫克该化合物，而对管路加人工肾进行类似灌注则产生6.10毫克。接受血液透析的患者透析后其血清中的平均浓度为751微克/升。接受超过50次血液透析治疗的患者透析后浓度显著高于接受较少次数治疗的患者。在透析过程中，血液对邻苯二甲酸二（2-乙基己基）酯的摄取呈现两种模式。一组患者在3小时时达到最高浓度，另一组患者则在透析结束前呈稳定上升趋势。邻苯二甲酸二（2-乙基己基）酯似乎能迅速从血液中清除，大部分在透析结束后5至7小时内被清除。
