Brown M P, Gronwall R, Kroll W R, Beal C
Equine Vet J. 1984 Jul;16(4):371-3. doi: 10.1111/j.2042-3306.1984.tb01947.x.
Five foals from two to three days old were given a single oral dose of ampicillin trihydrate (20 mg/kg bodyweight [bwt]). Serum ampicillin concentrations were measured serially over a 24 h period. The study was repeated in the same foals at 16 to 21 days old. The mean peak serum ampicillin concentration at two to three days old was 5.0 micrograms/ml at 1 h after treatment; the mean peak serum concentration at 16 to 21 days old was 2.7 micrograms/ml at 2 h. The concentrations steadily declined and ampicillin was not detected in the serum from any of the foals by 24 h. Serum clearance averaged 17.7 ml/min/kg at two to three days and 35.8 ml/min/kg at 16 to 21 days.
给5匹2至3日龄的小马驹口服单剂量三水合氨苄西林（20毫克/千克体重）。在24小时内连续测量血清氨苄西林浓度。在这些小马驹16至21日龄时重复该研究。2至3日龄时，治疗后1小时血清氨苄西林平均峰值浓度为5.0微克/毫升；16至21日龄时，2小时血清平均峰值浓度为2.7微克/毫升。浓度稳步下降，到24小时时，所有小马驹的血清中均未检测到氨苄西林。2至3日龄时血清清除率平均为17.7毫升/分钟/千克，16至21日龄时为35.8毫升/分钟/千克。
