Brown M P, Stover S M, Kelly R H, Farver T B
Equine Vet J. 1982 Jan;14(1):83-5. doi: 10.1111/j.2042-3306.1982.tb02345.x.
Six adult mares were given a single dose of ampicillin trihydrate (250 mg/ml) intramuscularly at a dosage of 20 mg/kg body weight. Serum, synovial fluid, peritoneal fluid and urine ampicillin concentrations were measured serially over a 48 h period. The mean peak serum ampicillin concentration was 2.49 micrograms/ml at 6 h. Ampicillin was found in synovial fluid and peritoneal fluid, which obtained mean peak ampicillin concentrations of 1.65 micrograms/ml and 1.81 micrograms/ml at 6 h and 4 h respectively. These concentrations declined in parallel with serum concentrations and were still detectable at 48 h. Urine concentration of ampicillin was relatively high, with a mean peak concentration of 1364.9 micrograms/ml at 4 h.
六匹成年母马以20毫克/千克体重的剂量肌肉注射单剂量三水合氨苄西林（250毫克/毫升）。在48小时内连续测量血清、滑液、腹腔液和尿液中的氨苄西林浓度。血清氨苄西林平均峰值浓度在6小时时为2.49微克/毫升。在滑液和腹腔液中发现了氨苄西林，其平均峰值氨苄西林浓度分别在6小时和4小时时为1.65微克/毫升和1.81微克/毫升。这些浓度与血清浓度平行下降，在48小时时仍可检测到。尿液中氨苄西林浓度相对较高，在4小时时平均峰值浓度为1364.9微克/毫升。
