Shugaev V A
Farmakol Toksikol. 1984 Jul-Aug;47(4):94-7.
Long-term inhalations of fluoride at concentrations of 0.58 and 2.75 mg/m3 distrub oxygen regimen in experimental animals (O2 consumption, tension and utilization in the muscle, tissue respiration). During fluorine intoxication, some of the antihypoxic agents (NAD X H, adenine nucleotides, guthimin, bemitil, apressin and glutamic acid) exert a beneficial therapeutic effect. Administration of the glycolysis substrates, NAD, NADP, cytochrome c and sodium hydroxybutyrate, did not exert any marked therapeutic action.
长期吸入浓度为0.58和2.75毫克/立方米的氟会干扰实验动物的氧代谢（肌肉中的氧气消耗、张力和利用率、组织呼吸）。在氟中毒期间，一些抗缺氧剂（烟酰胺腺嘌呤二核苷酸、腺嘌呤核苷酸、谷胱甘肽、贝美替尼、阿普加压素和谷氨酸）发挥有益的治疗作用。给予糖酵解底物、烟酰胺腺嘌呤二核苷酸、烟酰胺腺嘌呤二磷酸、细胞色素c和羟基丁酸钠未产生任何显著的治疗作用。
