Chu I, Villeneuve D C, Secours V E, Yagminas A, Reed B, Valli V E
Fundam Appl Toxicol. 1984 Aug;4(4):547-57. doi: 10.1016/0272-0590(84)90044-7.
This study was designed to provide information on the subchronic toxicity of octachlorostyrene (OCS), a demonstrated environmental pollutant in fish from the Great Lakes of North America and the Norwegian coast in Europe. Groups of 15 male and 15 female rats were administered OCS mixed in the diet at 0.05, 0.5, 5.0, 50, or 500 ppm for 13 weeks. Increased liver weights were observed in male and female rats fed 50 ppm OCS and higher, while enlarged kidney and spleen were noted in the highest dose groups. Hepatic microsomal enzyme induction occurred at 5.0 ppm OCS and higher for the males and 50 ppm and higher for the females. The chemical produced serum biochemical changes at concentrations as low as 5.0 ppm. OCS treatment resulted in hematological disturbances starting with the 0.5-ppm dose group. Dose-dependent histological changes were observed in the thyroid, kidneys, and liver of the treated animals. OCS residues accumulated in a dose-related fashion in the liver and fat of treated animals. These results indicate that OCS produced toxic effects at low levels of exposure and accumulated in the tissues of rats.
本研究旨在提供有关八氯苯乙烯（OCS）亚慢性毒性的信息，OCS是北美五大湖和欧洲挪威海岸鱼类中已证实的环境污染物。将15只雄性和15只雌性大鼠分为几组，分别给予含0.05、0.5、5.0、50或500 ppm OCS的混合饲料，持续13周。在摄入50 ppm及更高剂量OCS的雄性和雌性大鼠中观察到肝脏重量增加，而在最高剂量组中发现肾脏和脾脏肿大。雄性大鼠在摄入5.0 ppm及更高剂量的OCS时以及雌性大鼠在摄入50 ppm及更高剂量的OCS时出现肝微粒体酶诱导。该化学物质在低至5.0 ppm的浓度下就会引起血清生化变化。OCS处理从0.5 ppm剂量组开始导致血液学紊乱。在受试动物的甲状腺、肾脏和肝脏中观察到剂量依赖性组织学变化。OCS残留物在受试动物的肝脏和脂肪中以剂量相关的方式积累。这些结果表明，OCS在低暴露水平下产生毒性作用并在大鼠组织中积累。
