Chu I, Villeneuve D C, Secours V E, Valli V E, Leeson S, Shen S Y
Fundam Appl Toxicol. 1986 Jan;6(1):69-77. doi: 10.1016/0272-0590(86)90265-4.
This study was designed to investigate the toxic effects produced by the long-term exposure to octachlorostyrene (OCS), a demonstrated environmental contaminant in the Great Lakes region of North America and the Norwegian Coast in Europe. Groups of 20 male and 20 female rats were administered OCS in diets at 0.005, 0.05, 0.5, 5.0, or 50 ppm for 12 months. Weight gain and food consumption were not affected. Increased liver weights were observed in the groups fed the highest dose of OCS. Hepatic microsomal aniline hydroxylase and aminopyrine demethylase activities were induced in male rats fed 5.0 ppm OCS and higher and in female rats fed 50 ppm of the chemical. Elevated serum cholesterol levels were seen in rats of both sexes fed the highest dose. Treatment-related histological changes occurred in the thyroid, liver, and kidney of rats. A dose-dependent accumulation of OCS in the fat and liver of the rats was found. Based on the data presented, it was concluded that the no adverse effect level of OCS was 0.5 ppm.
本研究旨在调查长期接触八氯苯乙烯（OCS）所产生的毒性作用。OCS是北美五大湖地区和欧洲挪威海岸一种已被证实的环境污染物。将20只雄性和20只雌性大鼠分为几组，分别给予含0.005、0.05、0.5、5.0或50 ppm OCS的饲料，持续12个月。体重增加和食物消耗未受影响。在喂食最高剂量OCS的组中观察到肝脏重量增加。在喂食5.0 ppm及以上OCS的雄性大鼠和喂食50 ppm该化学品的雌性大鼠中，肝微粒体苯胺羟化酶和氨基比林脱甲基酶活性受到诱导。在喂食最高剂量的雌雄大鼠中均观察到血清胆固醇水平升高。大鼠的甲状腺、肝脏和肾脏出现了与治疗相关的组织学变化。在大鼠的脂肪和肝脏中发现了OCS的剂量依赖性蓄积。根据所呈现的数据，得出结论：OCS的无不良反应水平为0.5 ppm。
