Becci P J, Reagan E L, Wedig J H, Barbee S J
Fundam Appl Toxicol. 1984 Aug;4(4):587-93. doi: 10.1016/0272-0590(84)90048-4.
Teratogenesis studies were performed in rats and rabbits given N-cyclohexyl-2-pyrrolidone, an aprotic solvent used in chemical processing. Dosages of 0, 15, 50, 150, or 500 mg N-cyclohexyl-2-pyrrolidone/kg body wt/day were administered by gavage to groups of 25 pregnant Sprague-Dawley rats on Days 6 through 15 of gestation. Dosages of 0, 10, 30, 100, or 300 mg/kg/day were administered by gavage to groups of at least 15 pregnant Dutch-Belted rabbits on Days 6 through 18 of gestation. Animals were killed and subjected to uterine examination on Day 20 of gestation for rats and on Day 29 for rabbits. There were no significant differences between the vehicle control and N-cyclohexyl-2-pyrrolidone-treated groups for implantation numbers or live or dead fetuses, resorptions, and fetal body weight in rats and rabbits. Dam body weight gain during gestation was comparable among groups. External gross visual examination of the fetus as well as examination of skeletal and soft tissues revealed no effects related to treatment with N-cyclohexyl-2-pyrrolidone.
对使用N - 环己基 - 2 - 吡咯烷酮（一种用于化学加工的非质子溶剂）的大鼠和兔子进行了致畸研究。在妊娠第6天至第15天，通过灌胃法将剂量为0、15、50、150或500毫克N - 环己基 - 2 - 吡咯烷酮/千克体重/天给予25只怀孕的斯普拉格 - 道利大鼠组。在妊娠第6天至第18天，通过灌胃法将剂量为0、10、30、100或300毫克/千克/天给予至少15只怀孕的荷兰带兔组。在妊娠第20天对大鼠和第29天对兔子实施安乐死并进行子宫检查。在大鼠和兔子中，赋形剂对照组与用N - 环己基 - 2 - 吡咯烷酮处理的组之间在着床数、活胎或死胎、吸收胎以及胎儿体重方面没有显著差异。各组间妊娠期间母鼠体重增加情况相当。对胎儿进行外部大体视觉检查以及对骨骼和软组织进行检查，未发现与用N - 环己基 - 2 - 吡咯烷酮处理相关的影响。
