Becci P J, Reagan E L, Knickerbocker M J, Barbee S J, Wedig J H
Toxicol Appl Pharmacol. 1983 Dec;71(3):323-9. doi: 10.1016/0041-008x(83)90019-4.
o-Toluenediamine in corn oil was administered po to Sprague-Dawley rats at dosages of 10, 30, 100, or 300 mg/kg body wt/day during Days 6 through 15 of gestation. All animals were killed on Day 20 of gestation. A similar study was conducted with Dutch-Belted rabbits dosed po daily at 3, 10, 30, or 100 mg of o-toluenediamine/kg body wt/day from Days 6 through 18 of gestation. Rabbits were killed on Day 29 of gestation. Maternal toxicity was indicated at 300 mg/kg in rats and 100 mg/kg in rabbits by reduced body weight gain during gestation. Fetal body weight was reduced at the highest dosage in both rats and rabbits. In addition, at the high dosage, an increase in the number of resorption sites in rabbits were noted. Skeletal examination of rats showed increased incidence of missing sternebrae at 300 mg/kg and incompletely ossified vertebrae at 100 and 300 mg/kg in comparison to control fetuses. The effects on the fetus could be the result of maternal toxicity. There was no evidence of teratogenic effects or effects on the dams at dosages through 30 mg/kg body wt.
在妊娠第6天至15天期间，将玉米油中的邻甲苯二胺以10、30、100或300毫克/千克体重/天的剂量经口给予斯普拉格-道利大鼠。所有动物在妊娠第20天处死。对荷兰带兔进行了一项类似研究，在妊娠第6天至18天期间，每天经口给予3、10、30或100毫克邻甲苯二胺/千克体重/天。兔子在妊娠第29天处死。大鼠中300毫克/千克和兔子中100毫克/千克剂量时出现母体毒性，表现为妊娠期体重增加减少。大鼠和兔子在最高剂量时胎儿体重均降低。此外，高剂量时，兔子中吸收部位数量增加。与对照胎儿相比，大鼠的骨骼检查显示，300毫克/千克剂量时胸骨缺失发生率增加，100和300毫克/千克剂量时椎骨骨化不完全发生率增加。对胎儿的影响可能是母体毒性的结果。在30毫克/千克体重以下剂量时，没有致畸作用或对母鼠有影响的证据。
