黄疸患者的抗凝血酶III、纤溶酶原和α2抗纤溶酶。临床应用及预后意义。
Antithrombin III, plasminogen and alpha 2 antiplasmin in jaundice. Clinical usefulness and prognostic significance.
作者信息
Rodzynek J J, Urbain D, Leautaud P, Wettendorff P, Delcourt A
出版信息
Gut. 1984 Oct;25(10):1050-6. doi: 10.1136/gut.25.10.1050.
In this prospective study, antithrombin III, plasminogen and alpha 2 antiplasmin which are synthetised by the liver were measured and compared with the Normotest, Thrombotest and fibrinogen concentrations in 92 consecutive jaundiced patients. Antithrombin III appeared to be the most discriminant coagulation test in differentiating hepatocellular from cholestatic jaundice. A high correlation was observed between antithrombin III, plasminogen and alpha 2 antiplasmin values suggesting that the liver synthesis of these parameters was closely linked. The prognostic significance of the blood coagulation tests in patients with jaundice has been studied. In parenchymatous liver disease, antithrombin III, plasminogen and alpha 2 antiplasmin were superior to the Normotest, Thrombotest and fibrinogen concentrations in predicting the prognosis of the patients at the time of admission. In cholestatic jaundice, however, none of the blood coagulation tests studied had a prognostic significance.
在这项前瞻性研究中，对92例连续的黄疸患者测定了由肝脏合成的抗凝血酶III、纤溶酶原和α2抗纤溶酶，并将其与正常凝血检测、凝血酶检测及纤维蛋白原浓度进行比较。在区分肝细胞性黄疸与胆汁淤积性黄疸方面，抗凝血酶III似乎是最具鉴别力的凝血检测指标。观察到抗凝血酶III、纤溶酶原和α2抗纤溶酶值之间存在高度相关性，提示这些参数的肝脏合成密切相关。已对黄疸患者凝血检测的预后意义进行了研究。在实质性肝病中，抗凝血酶III、纤溶酶原和α2抗纤溶酶在预测患者入院时的预后方面优于正常凝血检测、凝血酶检测及纤维蛋白原浓度。然而，在胆汁淤积性黄疸中，所研究的凝血检测均无预后意义。
Zotero 插件