Burkhardt H, Graul E H, Pfab R, Schuster O, Loew D
Fortschr Med. 1984 Jul 26;102(27-28):735-9.
20 patients with an average age of 73.3 years suffering from left cardiac insufficiency in stage II to III of the NYHA, who could not be recompensated alone by means of digitalisation, received additionally the diuretic combination furosemide-retard (30 mg)/triamterene (50 mg) for 2 to 3 weeks. Subjective side effects were not observed. The laboratory parameters did not show any substantial changes. A short increase of uric acid and serum creatinine in the older patients returned to normal spontaneously. A decreased potassium level returned to normal; a hyperkaliemia was not observed. The repeated administration of the combination did not lead to any accumulation; only a balanced concentration at a low level appeared. The urine elimination, the decrease in body weight, the regression of the lung congestion and the size of the heart were statistically significant.
20例平均年龄73.3岁、患有纽约心脏协会（NYHA）II至III级左心功能不全且仅靠洋地黄化无法得到代偿的患者，额外接受了速尿缓释片（30毫克）/氨苯蝶啶（50毫克）利尿剂组合治疗2至3周。未观察到主观副作用。实验室参数未显示任何实质性变化。老年患者尿酸和血清肌酐短暂升高后自发恢复正常。降低的血钾水平恢复正常；未观察到高钾血症。该组合药物的重复给药未导致任何蓄积；仅出现低水平的平衡浓度。尿量、体重减轻、肺淤血消退及心脏大小在统计学上有显著意义。
