Bogardus J B
Hepatology. 1984 Sep-Oct;4(5 Suppl):148S-150S. doi: 10.1002/hep.1840040826.
The interaction of cholesterol with fatty acid salt solutions was investigated as a potential method for gallstone dissolution. In the presence of sodium oleate or laurate, crystalline cholesterol was rapidly converted into a lamellar liquid crystalline phase. Analysis of the mesophase showed that it contained approximately equimolar amounts of the lipid components, although water was the major constituent. The rate of conversion of cholesterol to mesophase was determined from a compressed disc immersed in a stirred solution, as if it were a simple dissolution process. The apparent rate of solubilization was independent of oleate concentration in the 2.5 to 10% range and was approximately 200 times faster than micellar dissolution of cholesterol in 5% sodium cholate. A mechanism is proposed in which the rate-limiting step in mesophase formation is dispersion of liquid crystalline fragments into the bulk medium.
研究了胆固醇与脂肪酸盐溶液的相互作用，将其作为一种潜在的胆结石溶解方法。在油酸钠或月桂酸钠存在的情况下，结晶胆固醇迅速转化为层状液晶相。对中间相的分析表明，尽管水是主要成分，但它含有近似等摩尔量的脂质成分。胆固醇向中间相的转化速率是通过将一个压缩圆盘浸入搅拌溶液中来测定的，就好像这是一个简单的溶解过程。在2.5%至10%的范围内，增溶的表观速率与油酸盐浓度无关，并且比胆固醇在5%胆酸钠中的胶束溶解快约200倍。提出了一种机制，其中中间相形成的限速步骤是液晶碎片分散到主体介质中。
