Barnes S
Hepatology. 1984 Sep-Oct;4(5 Suppl):98S-102S. doi: 10.1002/hep.1840040817.
Studies of bile salt structure using nuclear magnetic resonance (NMR) and X-ray crystallography have suggested that micellar association of bile salts is a function of side chain length and of packing of the side chain and the steroid nucleus. Lanthanide NMR probe analysis has been used to determine the structure of what is probably the monomer of the bile salt glycocholate. These approaches to the structural chemistry of bile salt intra- and intermolecular interactions are providing the basis for the design of artificial bile salt-like compounds for use in the study and treatment of human gallstone disease.
利用核磁共振（NMR）和X射线晶体学对胆盐结构进行的研究表明，胆盐的胶束缔合作用是侧链长度以及侧链与甾体核堆积情况的函数。镧系元素核磁共振探针分析已被用于确定胆盐甘氨胆酸可能的单体结构。这些研究胆盐分子内和分子间相互作用结构化学的方法，为设计用于人类胆结石疾病研究和治疗的人工类胆盐化合物提供了依据。
