Hong C Y, Chiang B N, Ku J, Wei Y H
Hum Toxicol. 1984 Aug;3(4):271-7. doi: 10.1177/096032718400300403.
The concentration-dependent inhibition of Neosampoon, a vaginal contraceptive, on ejaculated human sperm motility was studied with a transmembrane migration method. Caffeine (5mM), glutathione (5mM) and glutathione (15mM) all reactivated the motility of Neosampoon-immobilized sperm. Caffeine (5mM) was more potent than glutathione in antagonizing Neosampoon; there was no difference between the potency of 5mM- and 15mM-glutathione. Human sperm motility could be a model for studying the interaction of membrane-active drugs, including the protective effect of glutathione against membrane-disrupting agents.
采用跨膜迁移法研究了阴道避孕药新山宝（Neosampoon）对射出的人类精子活力的浓度依赖性抑制作用。咖啡因（5mM）、谷胱甘肽（5mM）和谷胱甘肽（15mM）均可使被新山宝固定的精子恢复活力。在拮抗新山宝方面，咖啡因（5mM）比谷胱甘肽更有效；5mM和15mM谷胱甘肽的效力没有差异。人类精子活力可作为研究膜活性药物相互作用的模型，包括谷胱甘肽对膜破坏剂的保护作用。
