阿米替林和丙咪嗪的精子制动效力：通过跨膜迁移测定。
Sperm immobilizing potency of amitriptyline and imipramine: measured with transmembrane migration.
作者信息
Hong C Y, Chiang B N, Ku J
出版信息
Arch Androl. 1984;12(1):25-8. doi: 10.3109/01485018409161143.
PMID:6476965
Abstract
The inhibitory effect of amitriptyline and imipramine on human sperm motility was measured in vitro with a transmembrane migration method. The EC50 for amitriptyline and imipramine were 170 microM and 160 microM respectively. They were more potent than any other drug that had been tested on this pharmacological model. Transmembrane migration method was less sensitive than turbidimetric method to detect the sperm immobilizing effect of drugs.
摘要
采用跨膜迁移法在体外测定了阿米替林和丙咪嗪对人精子活力的抑制作用。阿米替林和丙咪嗪的半数有效浓度（EC50）分别为170微摩尔/升和160微摩尔/升。它们比在此药理模型上测试过的任何其他药物都更有效。跨膜迁移法在检测药物的精子固定作用方面比比浊法灵敏度低。
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