Halonen M, Kaliner M
Int J Immunopharmacol. 1984;6(4):351-6. doi: 10.1016/0192-0561(84)90054-7.
Atopic humans express an array of autonomic nervous system abnormalities. An animal model of IgE-mediated allergy was herein employed to determine if the induction of an IgE antibody response would affect autonomic responsiveness. Rabbits were immunized so as to selectively produce IgE antibodies, and their pupillary miotic and mydriatic responses to cholinergic and alpha adrenergic stimuli, respectively, were determined. IgE-producing rabbits exhibited hyperresponsiveness to cholinergic but not alpha adrenergic stimulation, a pattern resembling that seen in nonasthmatic atopic humans. Repeated sublethal anaphylactic episodes induced in three IgE-producing rabbits did not affect the pattern of autonomic responsiveness when compared to controls challenged with saline, despite clear evidence of increased plasma histamine levels immediately after antigen challenges in the IgE group. This study indicates that elicitation of an IgE antibody response is associated with the concomitant development of cholinergic hyper-responsiveness.
特应性个体表现出一系列自主神经系统异常。本文采用一种IgE介导的过敏动物模型来确定IgE抗体反应的诱导是否会影响自主反应性。对兔子进行免疫以选择性产生IgE抗体，并分别测定它们对胆碱能和α肾上腺素能刺激的瞳孔收缩和扩张反应。产生IgE的兔子对胆碱能刺激表现出高反应性，但对α肾上腺素能刺激无此反应，这一模式与非哮喘特应性个体所见相似。与用盐水激发的对照组相比，在三只产生IgE的兔子中诱导的反复亚致死性过敏反应并未影响自主反应性模式，尽管有明确证据表明IgE组在抗原激发后立即血浆组胺水平升高。这项研究表明，IgE抗体反应的引发与胆碱能高反应性的同时出现有关。
