烟草花叶病毒基因表达的调控
Regulation of tobamovirus gene expression.
作者信息
Dawson W O, Lehto K M
机构信息
Department of Plant Pathology, University of California, Riverside 92521.
出版信息
Adv Virus Res. 1990;38:307-42. doi: 10.1016/s0065-3527(08)60865-9.
Abstract
This chapter discusses tobacco mosaic virus (TMV) strains U1, OM, L, CGMMV, 0, and Cc. The production of each TMV protein is regulated differently, both in amounts and times of production. The chapter discusses some of the strategies that tobamoviruses uses to control gene expression: (1) different subgenomic RNA promoter/leader sequences control timing of expression of genes, (2) genes expressed via subgenomic mRNAs are expressed in decreasing amounts with increasing distances from the 3' terminus, and (3) TMV mRNAs appear to be translationally regulated differently from host mRNAs. Genome organization affects gene expression, but it appears to be equally important for the efficiency of replication and the ability of the genomic structure to be stably propagated. Different virus groups have evolved different gene arrangements. Tobamovirus genes expressed via subgenomic mRNAs appear to be expressed in increasing amounts when positioned nearer the 3’ terminus.
摘要
本章讨论了烟草花叶病毒（TMV）的U1、OM、L、黄瓜绿斑驳花叶病毒（CGMMV）、0和Cc毒株。每种TMV蛋白的产生在数量和产生时间上都受到不同的调控。本章讨论了烟草花叶病毒用于控制基因表达的一些策略：（1）不同的亚基因组RNA启动子/前导序列控制基因表达的时间，（2）通过亚基因组mRNA表达的基因，随着与3'末端距离的增加，表达量逐渐减少，（3）TMV mRNA的翻译调控似乎与宿主mRNA不同。基因组组织影响基因表达，但它对于复制效率和基因组结构稳定传播的能力似乎同样重要。不同的病毒组进化出了不同的基因排列方式。通过亚基因组mRNA表达的烟草花叶病毒基因，当位于更靠近3'末端时，表达量似乎会增加。
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