Serio C S, Henning C B, Toohey R E, Lloyd E L
Health Phys. 1984 Aug;47(2):309-13.
Sera from former Ra workers were incubated with normal human lymphocytes and the effects produced in stimulation assays with specific mitogens were compared with those observed with incubation using normal human sera. The sera from the Ra workers with high residual body burdens (greater than 0.1 muCi 226Ra) inhibited normal control lymphocytes stimulated with Con A and PHA when compared with control homologous sera. Although a significant suppression was not obtained between high- and low-body-burden groups a trend was indicated. Sera from the highest body-burden worker (0.58 muCi) was inhibitory to all normal lymphocyte populations tested regardless of the mitogen stimulant employed.
将曾从事镭工作的人员的血清与正常人淋巴细胞一起孵育，并将在特定有丝分裂原刺激试验中产生的效应与使用正常人血清孵育时观察到的效应进行比较。与对照同源血清相比，镭残留量高（大于0.1微居里226镭）的镭作业人员的血清抑制了由刀豆球蛋白A和植物血凝素刺激的正常对照淋巴细胞。虽然在高体内负荷组和低体内负荷组之间未获得显著抑制，但显示出一种趋势。体内负荷最高的工作人员（0.58微居里）的血清对所有测试的正常淋巴细胞群体均有抑制作用，无论使用何种有丝分裂原刺激剂。
