Yalon M, Blumenthal M, Goldberg E P
J Am Intraocul Implant Soc. 1984 Summer;10(3):315-7. doi: 10.1016/s0146-2776(84)80003-8.
Soft hydrophilic intraocular lenses (IOLs) made of an aminopolyamide (Duragel) and a hydroxyethylmethylmethacrylate (HEMA) hydrogel polymer were implanted in cats and followed for six weeks. During surgery, a 45-second purposeful contact between the lens surface and the corneal endothelium was made. During the course of the experiment, all implanted eyes maintained clear IOLs and manifested a continuing mild iritis. Scanning electron microscopy of the corneas revealed numerous microvilli but no damage to cell membranes. Scanning electron microscopy of the aminopolyamide IOLs revealed fibroblast growth on the surface. No fibroblast growth was noted on the surface of the HEMA IOLs. These experiments suggest that soft hydrogel IOLs may be better than conventional hydrophobic acrylic IOLs in minimizing endothelial contact damage. However, the observation of corneal microvilli may indicate a mild adverse reaction to the hydrogels, possibly from impurities. Fibroblast growth on the aminopolyamide may also be due to an ocular inflammatory response to the material or impurities. Hydrogel IOLs may be of interest because of their semirigid physical properties and greater safety on contacting the endothelium. However, considerable attention must be given to polymer composition and polymer purification.
由氨基聚酰胺（Duragel）和甲基丙烯酸羟乙酯（HEMA）水凝胶聚合物制成的软性亲水性人工晶状体（IOL）被植入猫体内，并随访六周。手术过程中，使晶状体表面与角膜内皮有45秒的有意接触。在实验过程中，所有植入眼的人工晶状体均保持清晰，并表现出持续的轻度虹膜炎。角膜的扫描电子显微镜检查显示有大量微绒毛，但细胞膜无损伤。氨基聚酰胺人工晶状体的扫描电子显微镜检查显示表面有成纤维细胞生长。在HEMA人工晶状体表面未观察到成纤维细胞生长。这些实验表明，软性水凝胶人工晶状体在使内皮接触损伤最小化方面可能优于传统的疏水性丙烯酸人工晶状体。然而，角膜微绒毛的观察可能表明对水凝胶有轻度不良反应，可能源于杂质。氨基聚酰胺表面的成纤维细胞生长也可能是由于眼部对该材料或杂质的炎症反应。水凝胶人工晶状体因其半刚性物理性质和接触内皮时更高的安全性可能会受到关注。然而，必须高度重视聚合物组成和聚合物纯化。
