Sattler T A, Dimitrov T, Hall P W
Lancet. 1977 Feb 5;1(8006):278-80. doi: 10.1016/s0140-6736(77)91824-4.
Serum and urine beta 2-microglobulin concentrations were determined in 38-6% of the 869 inhabitants of a village in which both Balkan endemic nephropathy and papillary tumours of the urinary-tract epithelium are common. Over 23% of the "healthy" population had raised serum and/or urine beta 2-microglobulin. 5 of 6 patients with papillary tumours of the renal pelvis, without evidence of renal parenchymal involvement, and 13-4% of the "healthy" population had raised serum-beta 2-microglobulin. It is suggested that overproduction of beta 2-microglobulin, a light-chain-like immune globulin, by the tumour cells may result in a light-chain-like nephropathy--i.e., endemic Balkan nephropathy.
在一个巴尔干地方性肾病和泌尿道上皮乳头状肿瘤都很常见的村庄的869名居民中，38.6%的人检测了血清和尿液β2-微球蛋白浓度。超过23%的“健康”人群血清和/或尿液β2-微球蛋白升高。6例肾盂乳头状肿瘤患者中，5例无肾实质受累证据，其血清β2-微球蛋白升高，“健康”人群中有13.4%血清β2-微球蛋白升高。有人提出，肿瘤细胞过度产生β2-微球蛋白（一种轻链样免疫球蛋白）可能导致轻链样肾病，即地方性巴尔干肾病。
