Radonic M
Pathol Biol (Paris). 1978 Sep;26(6):317-20.
The results of low molecular weight (LMW) proteinuria test in urines of patients and suspect subjects in an endemic area of Balkan endemic nephropathy (BEN) in Yugoslavia are reported. An accordance between the positive LMW test and the clinical diagnosis of BEN has been found in more than 70%. The authors claim that LMW immunodiffusion test is a very useful procedure for detecting BEN and a great aid in the epidemiological work in the endemic field. The results of determining beta2-microglobuline (beta2m) in serums and urines by radioimmunoassay technique as well as counting of clearances of endogenous creatinine in healthy persons, "endangered" subjects in endemic area, and BEN patients without azotemia, with azotemia and uremia are reported. The group of 17 patients suffering of BEN without azotemia having slightly or more markedly lowered creatinine clearances showed higher serum and much higher urinary concentration of beta2m which are not in proportion with creatinine clearance. The results are interpreted so far as a consequence of the predominant tubular lesion in BEN. In groups of patients with azotemia and uremia no differences in beta2m handling have been found. The report has a preliminary character and requires further study.
本文报道了在南斯拉夫巴尔干地方性肾病（BEN）流行区患者及疑似患者尿液中低分子量（LMW）蛋白尿检测的结果。超过70%的LMW检测阳性结果与BEN的临床诊断相符。作者声称，LMW免疫扩散试验是检测BEN的一种非常有用的方法，对流行区的流行病学工作有很大帮助。本文还报道了采用放射免疫分析技术测定血清和尿液中β2-微球蛋白（β2m）的结果，以及对健康人、流行区“高危”人群、无氮质血症、有氮质血症和尿毒症的BEN患者进行内生肌酐清除率计数的结果。17例无氮质血症的BEN患者组，其肌酐清除率轻度或明显降低，血清β2m浓度较高，尿β2m浓度更高，且与肌酐清除率不成比例。目前认为这些结果是BEN主要肾小管病变的结果。在有氮质血症和尿毒症的患者组中，未发现β2m处理存在差异。本报告具有初步性质，需要进一步研究。
